: Abstract

applications of complexes are very important in different sectors like the pharmaceutical industrial. So, this study aimed to preparation sodium salts of amino acids complexes by using K2PtCl6, Cu (NO3)2.3H2O, HgCl2 and ZnCl2 as a ligand reaction with the sodium salts of the following amino acids: glycine (glyH), L-alanine (alaH), L-phenylalanine (pheH). The following complexes were isolated: Na [Pt(gly)Cl4] .0.5C2H5OH, [Cu(ala)2].0.5C2H5OH, [Pt(ala)3Cl].C2H5OH.4H2O, [Pt(phe)2Cl2].0.5C2H5OH.1.5H2O, [Hg(phe)2].9H2O, [Zn(phe)2].C2H5OH. The isolated complexes have been characterized by their elemental analysis’s solubility, conductivity measurements, IR, electronic absorption and C13 NMR spectra.

Keywords: Metal complexes, Amino acids, Characterization.

الملخص:

تطبيقات المعقدات مهمة جد ا في مجاالت مختلفة مثل الصناعات الدوائية، عليه است هدفت هذه الدراسة تح ضير معقدات أمالح الصوديوم أمالح مع الليكاندات كتفاعالت K2PtCl6, Cu (NO3)2.3H2O, HgCl2 and ZnCl2 معقدات بواسطة الصوديوم لألحماض األميني ة التالية: الجاليسي ين (glyH(، L- أالنين (alaH(، L- فينيل أالنين )pheH). وت م الحصول على ست معقدات مختلفة: Na [Pt(gly)Cl4] .0.5C2H5OH, [Cu(ala)2].0.5C2H5OH, [Pt(ala)3Cl].C2H5OH.4H2O, [Pt(phe)2Cl2].0.5C2H5OH.1.5H2O, [Hg(phe)2].9H2O, [Zn(phe)2].C2H5OH تم تشخيص هذه المركبات عن طريق تحليل العناصر المكونة لها وايجاد نسبتها باإلضافة إلى استعمال الطرق الفيزيائ ية األتية: درجة االنصهار، الذائ ب ية، التوصيل الكهربائي لمحاليلها، واألطي اف تحت الحمراء والمرئية وفوق البنفسجية إلى الرنين المغناطيسي.

الكلمات المفتاحية: المعقدات، األحماض األمينية، التشخيص.

:Abstract

This project includes and in deification the complexes of amino acid L-serine (serH) L-cysteine (cysH) , and L-threonin (thrH₂) with some ions of trace elements such as K₂ptCl₆ ,

Cu(NO₃)₂.3H₂O , ZnCl₂ and HgCl₂ were studied by Infrared-spectra ‘NMR from this identification studies can give the structure formed for the complexes with were prepare with amino acids :

Na[pt(ser)Cl₄] .0.5C₂H₅OH   ,[Hg(ser)₂] .9H₂O , [Cu(ser)₂] , Na[pt(cys)₂Cl₃].0.5C₂H₅OH.3H₂O and

Keywords: metal complexes – Amino acids – Characterization .

الملخص:                                                                                                                                                              تم في هذا البحث تحضير وتشخيص بعض المعقدات من تفاعل بعض من ايونات العناصر هي : Z(II) , Cu(II) , Pt(IV) , Hg(II)    مع الأحماض الأمينية مثل السستايين و السيرين و الثرونين و التي شخصت بعدة طرق منها طيف الأشعة تحت الحمراء والمرئية وفوق البنفسجية بالأضافة الى استعمال الطرق الفيزيائية الأتية : درجة الأنصهار والذائيبية والتوصيل الكهربائي لمحاليلها .

الكلمات المفتاحية : الأحماض الأمينية – المعقدات – التشخيص

.

Abstract:

The incessant use of mobile phones can be attributed to its portability and thus have become one of the most widely used devices in mobile communication which makes it so essential in our lives.

The convenience and portability of mobile phones has made it possible to be carried everywhere, e.g. Mosques, lecture halls, medical centers etc. Its convenience can create inconvenience in some places when there is continuous beeping or ringtones of mobile phones which becomes annoying when such noise is disruptive in areas where silence is required or the use or of mobile phone is restricted or prohibited like Libraries and Study rooms.

The problem of microbial resistance continues to increase in all regions of the world, and even though a very large number of antibiotics have been produced in the last 30 years, microbial resistance is maintained because of the wide use of these drugs against many infectious diseases. Thus, natural products are seen as the alternative solution. Based on previous studies, Peganum harmala has been reported to exhibit several biological properties including antibacterial and antifungal. Thus, the main aim of this study is evaluating antibacterial activities of P. harmala against Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus, which isolated from infected patients in (Alassaba'a hospital, Alassaba'a, west of Tripoli). Agar disk diffusion technique was used for detecting the antibacterial activity, and the minimum inhibitory concentration was tested by serial dilution methods. The results showed that the growth of all tested bacteria were inhibited strongly by methanol extract of seeds at 1.0% with inhibition zones 14.66, 12.00 and 15.33mm against E. coli, k. pneumoniae and S. aureus respectively. Besides, MIC values ranged between 0.625 to 1.25 mg/mL. While, MBC values ranging between 1.25 to 5 mg/mL. On the other hand, methanol extract of leaves was also inhibit the growth of E. coli, k. pneumoniae and S. aureus with inhibition zones 11.00, 9.66 and 10.00mm respectively. As well as, MIC values ranging between 1.25 to 2.5 mg/mL, while MBCs value ranging between 2.5 to 5 mg/mL . In conclusion, methanol extract of P. harmala seeds exhibited strongly antimicrobial activity against E. coli, k. pneumoniae and S. aureus, thus it can be developed as anti-bacterial agent.

الخلاصة:

تتناول المقالة الطرق الحالية لمعالجة النفايات البلدية الصلبة في سياق كفاءتها الشاملة. تم

إج ا رء اختبار تجريبي لتقنية فعالة وصديقة للبيئة لتغويز النفايات الصلبة بالبلازما، وأكدت النتائج

التي تم الحصول عليها إمكانية الحصول على غاز اصطناعي عالي السع ا رت الح ا ررية.