:Abstract

This project includes and in deification the complexes of amino acid L-serine (serH) L-cysteine (cysH) , and L-threonin (thrH₂) with some ions of trace elements such as K₂ptCl₆ ,

Cu(NO₃)₂.3H₂O , ZnCl₂ and HgCl₂ were studied by Infrared-spectra ‘NMR from this identification studies can give the structure formed for the complexes with were prepare with amino acids :

Na[pt(ser)Cl₄] .0.5C₂H₅OH   ,[Hg(ser)₂] .9H₂O , [Cu(ser)₂] , Na[pt(cys)₂Cl₃].0.5C₂H₅OH.3H₂O and

Keywords: metal complexes – Amino acids – Characterization .

الملخص:                                                                                                                                                              تم في هذا البحث تحضير وتشخيص بعض المعقدات من تفاعل بعض من ايونات العناصر هي : Z(II) , Cu(II) , Pt(IV) , Hg(II)    مع الأحماض الأمينية مثل السستايين و السيرين و الثرونين و التي شخصت بعدة طرق منها طيف الأشعة تحت الحمراء والمرئية وفوق البنفسجية بالأضافة الى استعمال الطرق الفيزيائية الأتية : درجة الأنصهار والذائيبية والتوصيل الكهربائي لمحاليلها .

الكلمات المفتاحية : الأحماض الأمينية – المعقدات – التشخيص

: Abstract

applications of complexes are very important in different sectors like the pharmaceutical industrial. So, this study aimed to preparation sodium salts of amino acids complexes by using K2PtCl6, Cu (NO3)2.3H2O, HgCl2 and ZnCl2 as a ligand reaction with the sodium salts of the following amino acids: glycine (glyH), L-alanine (alaH), L-phenylalanine (pheH). The following complexes were isolated: Na [Pt(gly)Cl4] .0.5C2H5OH, [Cu(ala)2].0.5C2H5OH, [Pt(ala)3Cl].C2H5OH.4H2O, [Pt(phe)2Cl2].0.5C2H5OH.1.5H2O, [Hg(phe)2].9H2O, [Zn(phe)2].C2H5OH. The isolated complexes have been characterized by their elemental analysis’s solubility, conductivity measurements, IR, electronic absorption and C13 NMR spectra.

Keywords: Metal complexes, Amino acids, Characterization.

الملخص:

تطبيقات المعقدات مهمة جد ا في مجاالت مختلفة مثل الصناعات الدوائية، عليه است هدفت هذه الدراسة تح ضير معقدات أمالح الصوديوم أمالح مع الليكاندات كتفاعالت K2PtCl6, Cu (NO3)2.3H2O, HgCl2 and ZnCl2 معقدات بواسطة الصوديوم لألحماض األميني ة التالية: الجاليسي ين (glyH(، L- أالنين (alaH(، L- فينيل أالنين )pheH). وت م الحصول على ست معقدات مختلفة: Na [Pt(gly)Cl4] .0.5C2H5OH, [Cu(ala)2].0.5C2H5OH, [Pt(ala)3Cl].C2H5OH.4H2O, [Pt(phe)2Cl2].0.5C2H5OH.1.5H2O, [Hg(phe)2].9H2O, [Zn(phe)2].C2H5OH تم تشخيص هذه المركبات عن طريق تحليل العناصر المكونة لها وايجاد نسبتها باإلضافة إلى استعمال الطرق الفيزيائ ية األتية: درجة االنصهار، الذائ ب ية، التوصيل الكهربائي لمحاليلها، واألطي اف تحت الحمراء والمرئية وفوق البنفسجية إلى الرنين المغناطيسي.

الكلمات المفتاحية: المعقدات، األحماض األمينية، التشخيص.

Nasal carriage of MRSA among hospital personnel is a big problem in hospital environment. Accordingly, the main objective of current study was to determine the prevalence of MRSA among Health Care Workers (HCWs) in Yafran hospital. 108 HCWs samples of nasal swabs were collected, and cultured on Mannitol Salt Agar. The isolates were identified as S. aureus based on morphology. Besides, confirmatory tests were performed, including coagulase and catalase test. Finally, cefoxitin disc resistance was used to identify the MRSA strain. Antibiotic susceptibility testing of MRSA was performed according to the guidelines of the Clinical and Laboratory Standards Institute .

The results showed that, out of the 108 HCWs, 37 (34%) carried MRSA. MRSA carriage rate was highest among Administration Department workers 30 % compared to other professions, followed by Emergency Department workers 21% , Obstetrics and Gynecology workers 19 %, Radiology, Laboratory and Internal Medicine Department workers was 8% ,5% and 5% respectively. Tetracycline showed the highest rate of resistance among MRSA isolates 27%, followed by Vancomycin 22%. While the Ciprofloxacin showed less resistance 11%. In conclusions, the high rate of nasal MRSA carriage among healthcare workers found in this study is alarming and highlights the need for adjusted infection control measures to prevent MRSA transmission from HCWs to the vulnerable patient .

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Urinary tract infections (UTIs) are common infections that happen by many types of bacteria. Some of bacteria have resistance against several types of antibiotics. Many medicinal plants used as an alternative treatment around the world. Marrubium vulgare L has been reported to exhibit several biological properties. Thus, the aim of current study is estimating antimicrobial activities of M. vulgare against Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus, which caused urinary tract infections, isolated from infected patients. In the results, the growth of all tested bacteria was inhibited strongly by methanol extract at 1.0% (w/v) with inhibition zones 11.00, 11.00 and 15.50 mm against E. coli, k. pneumoniae and S. aureus respectively. Besides, Minimum Inhibitory Concentration (MIC) values were ranged between 0.625 to 1.25 mg/mL. While, Minimum Bactericidal Concentration (MBC) values were ranging between 1.25 to 2.5 mg/mL. On the other hand, hexane extract also was inhibited the growth of E. coli, k. pneumoniae and S. aureus with inhibition zones 10.00, 11.00 and 12.50 mm respectively. In addition, MIC values ranging 2.5 mg/mL, while MBC values of 5 mg/mL against all bacteria.  In conclusion, the methanol extract of M. vulgare had a strongly effects on all bacteria compared to hexane extract, thus it can be developed as anti-bacterial agent.

Abstract:

The incessant use of mobile phones can be attributed to its portability and thus have become one of the most widely used devices in mobile communication which makes it so essential in our lives.

The convenience and portability of mobile phones has made it possible to be carried everywhere, e.g. Mosques, lecture halls, medical centers etc. Its convenience can create inconvenience in some places when there is continuous beeping or ringtones of mobile phones which becomes annoying when such noise is disruptive in areas where silence is required or the use or of mobile phone is restricted or prohibited like Libraries and Study rooms.